World Journal of Nuclear Medicine

INTERESTING CASES
Year
: 2020  |  Volume : 19  |  Issue : 4  |  Page : 455--456

18F-prostate-specific membrane antigen positron emission tomography computed tomography incidental finding in a patient after COVID-19 infection


Siroos Mirzaei1, Cherin Farhan1, Mario Karolyi2,  
1 Department of Nuclear Medicine with PET-Center, Klinik Ottakring, Vienna, Austria
2 Department for Infectious Diseases and Tropical Medicine, Klinik Favoriten (KFJ), Vienna, Austria

Correspondence Address:
Prof. Siroos Mirzaei
Department of Nuclear Medicine with PET-Center, Klinik Ottakring (Wilhelminenspital), Montleartstr. 37, A-1160, Vienna
Austria

Abstract

The COVID-19 pandemic has now reached most countries. However, the referred patients to a nuclear medicine department will be primarily the asymptomatic ones. We report the case of a patient (84-year-old male) who was sent for18F-prostate-specific membrane antigen positron emission tomography computed tomography (PSMA PET-CT) with suspicion of recurrent disease after prostate cancer and total prostatectomy 2 years prior to the examination. He suffered from COVID-19 pneumonia 4 weeks prior to PET-CT examination. The18F-PSMA PET-CT revealed moderate elevated uptake in the area of previous pneumonia in the right lung. The radiological findings showed ground glass changes in this area indicating possible residual inflammatory disease even weeks after infection.



How to cite this article:
Mirzaei S, Farhan C, Karolyi M. 18F-prostate-specific membrane antigen positron emission tomography computed tomography incidental finding in a patient after COVID-19 infection.World J Nucl Med 2020;19:455-456


How to cite this URL:
Mirzaei S, Farhan C, Karolyi M. 18F-prostate-specific membrane antigen positron emission tomography computed tomography incidental finding in a patient after COVID-19 infection. World J Nucl Med [serial online] 2020 [cited 2022 Aug 18 ];19:455-456
Available from: http://www.wjnm.org/text.asp?2020/19/4/455/297094


Full Text

 Introduction



The COVID-19 pandemic has now reached most countries. Emergency room and intensive care staff are at increased risk for infection, however, the referred patients to a nuclear medicine department will be primarily the asymptomatic ones. Therefore, good communication with referral physicians and safety measures are mandatory for the protection of other patients and staff.[1],[2]

In a recent publication, it was suggested that18F-fluorodeoxyglucose positron emission tomography computed tomography (PET-CT) can identify COVID-19 cases in the absence or before symptom onset and may guide patient management.[3]

 Case Report



We report the case of a patient (84-year-old male) who was sent for 18F-prostate-specific membrane antigen (PSMA) PET-CT with suspicion of recurrent disease after prostate cancer and total prostatectomy 2 years prior to the examination. The patient suffered from COVID-19 pneumonia 4 weeks prior to PET-CT examination.

The examination was performed as elsewhere described.[4] Briefly, PET-CT images were performed 1 h after intravenous injection of 248 MBq18F-PSMA on a PET-CT scanner (Siemens Healthineers, Erlangen) and the images were analyzed on a Syngovia Workstation (Siemens Healthineers, Erlangen). The18F-PSMA PET-CT revealed moderate elevated uptake in the area of previous pneumonia as shown in [Figure 1]. The patient had no respiratory symptoms and no other signs of infection at the time of PET examination. The radiological findings showed ground glass changes in this area. These pulmonary findings were interpreted as remaining inflammatory changes in an already recovered patient after Covid-19 infection, as it has been ascribed to PSMA uptake in inflammation elsewhere.[5]{Figure 1}

 Conclusion



To the best of our knowledge, this is the first case report with a pathological pulmonary uptake of a PSMA ligand with PET-CT in COVID-19 patients, indicating possible residual inflammatory disease even weeks after infection.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

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