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99mTc-PSMA SPECT/CT is superior to 99mTc-MDP SPECT/CT in the staging of prostatic cancer with osseous metastases after external beam radiotherapy

 Department of Nuclear Medicine, GH Klinikum Frankfurt (Oder), Frankfurt (Oder), Germany

Correspondence Address:
Knut Liepe,
Department of Nuclear Medicine, GH Klinikum Frankfurt (Oder), Muellroser Chaussee 7, 15236, Frankfurt (Oder)
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/wjnm.wjnm_46_21

In the reported patient with advanced prostate cancer, a bone scan showed false positive findings in the thoracic vertebrae after external beam radiotherapy two months ago. An additional 99mTc-PSMA SPECT/CT scan showed negative findings, although a non-irradiated iliac bone metastasis was concordantly positive in both scans. The decrease of PSA level from 154.6 ng/ml to 2.3 ng/ml indicates a strong effect of treatment, hence supporting that false positivity in bone scan is caused by the “flare phenomenon”.

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